|
1 / 1
|
DeCS
|
|
 |
|
Descriptor English:
|
|
Insulin Receptor Substrate Proteins
|
|
Descriptor Spanish:
|
|
Proteínas Sustrato del Receptor de Insulina
|
|
Descriptor Portuguese:
|
|
Proteínas Substratos do Receptor de Insulina
|
|
Synonyms English:
|
|
IRS Signaling Adaptor Proteins
Insulin Receptor Substrate-1
Insulin Receptor Substrate-1 Protein
Insulin Receptor Substrate-2
Insulin Receptor Substrate-2 Protein
Insulin Receptor Substrate-3
Insulin Receptor Substrate-3 Protein
Insulin Receptor Substrate-4
Insulin Receptor Substrate-4 Protein
Insulin Receptor Substrate 1
Insulin Receptor Substrate 1 Protein
Insulin Receptor Substrate 2
Insulin Receptor Substrate 2 Protein
Insulin Receptor Substrate 3
Insulin Receptor Substrate 3 Protein
Insulin Receptor Substrate 4
Insulin Receptor Substrate 4 Protein
|
|
Tree Number:
|
|
D12.644.360.024.301
D12.776.157.057.039
D12.776.476.024.382
|
|
Definition English:
|
|
A structurally-related group of signaling proteins that are phosphorylated by the INSULIN RECEPTOR PROTEIN-TYROSINE KINASE. The proteins share an N-terminal PLECKSTRIN HOMOLOGY DOMAIN, a phosphotyrosine-binding domain that interacts with the phosphorylated INSULIN RECEPTOR, and a C-terminal TYROSINE-rich domain. Upon tyrosine phosphorylation, insulin receptor substrate proteins interact with specific SH2 DOMAIN containing proteins that are involved in insulin receptor signaling. |
|
History Note English:
|
|
2009(1992)
|
|
Allowable Qualifiers English:
|
|
|
|
Record Number:
|
|
53148
|
|
Unique Identifier:
|
|
D055504
|
Occurrence in VHL:
|
|
|
Similar:
|
|
DeCS CID-10 SciELO LILACS LIS
|